Following the recognition of pathogen-encoded effectors, plant TIR-NB-LRR immune receptors induce defense signaling by a largely unknown mechanism.We identify a novel and conserved role for the SQUAMOSA PROMOTER BINDING PROTEIN (SBP)-domain transcription factor SPL6 in enabling the activation of the defense transcriptome following its association w
IntroductionObservational studies have reported the association between gut microbiota and the risk of lower respiratory tract infections (LRTIs).However, whether the association reflects a causal relationship remains obscure.MethodsA bidirectional twosample Mendelian randomization (MR) analysis was conducted by assessing genome-wide association st
Protein kinases play a central role in tumor progression, regulating fundamental processes such as angiogenesis, proliferation and metastasis.Such enzymes are an increasingly important class of drug target with small molecule kinase inhibitors being a major focus in drug development.However, balancing drug specificity and efficacy is problematic wi
In the era of the COVID-19 pandemic, questions regarding the participation of temporary foreign workers (TFWs) in the Canadian workforce may seem reasonable.With borders closed to most international traffic due to public health concerns, and high levels of unemployment, the Canadian public, policy makers, and even employers may question the need to